npj Aging
Scope & Guideline
Advancing knowledge on the complexities of aging.
Introduction
Aims and Scopes
- Cellular and Molecular Mechanisms of Aging:
Research focusing on the cellular and molecular pathways that contribute to aging, including studies on senescence, oxidative stress, and mitochondrial dysfunction. - Cognitive Aging and Neurodegeneration:
Investigations into the cognitive aspects of aging, including the mechanisms behind cognitive decline, neurodegenerative diseases like Alzheimer's, and potential biomarkers for early diagnosis. - Interventions and Therapies:
Exploration of various interventions, including pharmacological treatments, lifestyle modifications, and regenerative medicine approaches aimed at mitigating age-related decline and enhancing healthspan. - Environmental and Lifestyle Factors:
Studies examining the impact of diet, exercise, and environmental factors on the aging process and their role in promoting healthy aging. - Health Economics and Policy:
Research addressing the implications of aging populations on healthcare systems, including cost analyses and strategies for managing age-related diseases.
Trending and Emerging
- Senescence and Senotherapeutics:
There is a growing emphasis on understanding cellular senescence and the development of senotherapeutics, reflecting an increasing interest in targeting senescent cells to improve health outcomes. - Multi-Omics Approaches:
The integration of multi-omics data (genomics, proteomics, metabolomics) in aging research is on the rise, facilitating a more comprehensive understanding of the biological processes underlying aging. - Digital Health and Technology in Aging Research:
Research utilizing digital tools and technologies, such as machine learning and wearable devices, to monitor and assess cognitive decline and other age-related changes is becoming increasingly prominent. - Environmental and Lifestyle Interventions:
An emerging focus on how lifestyle factors and environmental influences, such as diet and exercise, interact with biological aging processes to promote healthy aging. - Chronic Disease Interplay with Aging:
Increasing attention is being paid to how chronic diseases, such as diabetes and cardiovascular conditions, intersect with aging processes, influencing overall health and longevity.
Declining or Waning
- Genetic Studies in Aging:
Research focusing on genetic factors influencing aging has become less prevalent, possibly due to a shift towards more integrative approaches that combine genetic, environmental, and lifestyle factors. - Traditional Models of Aging:
Studies utilizing traditional aging models, such as specific inbred mouse strains, have seen a decline in favor of more innovative models, including heterochronic parabiosis and multi-species approaches. - Single-Factor Analysis of Aging:
There is a noticeable reduction in studies that analyze aging through a single-factor lens, such as focusing solely on one type of cellular or molecular mechanism, as researchers increasingly adopt multidisciplinary perspectives.
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