Nucleic Acid Therapeutics

Scope & Guideline

Advancing the Future of Molecular Medicine.

Introduction

Welcome to the Nucleic Acid Therapeutics information hub, where our guidelines provide a wealth of knowledge about the journal’s focus and academic contributions. This page includes an extensive look at the aims and scope of Nucleic Acid Therapeutics, highlighting trending and emerging areas of study. We also examine declining topics to offer insight into academic interest shifts. Our curated list of highly cited topics and recent publications is part of our effort to guide scholars, using these guidelines to stay ahead in their research endeavors.
LanguageEnglish
ISSN2159-3337
PublisherMARY ANN LIEBERT, INC
Support Open AccessNo
CountryUnited States
TypeJournal
Convergefrom 2011 to 2024
AbbreviationNUCLEIC ACID THER / Nucl. Acid Ther.
Frequency6 issues/year
Time To First Decision-
Time To Acceptance-
Acceptance Rate-
Home Page-
Address140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801

Aims and Scopes

Nucleic Acid Therapeutics focuses on the development and application of nucleic acid-based therapies, particularly oligonucleotides, for treating various diseases. The journal emphasizes innovative methodologies and therapeutic strategies that leverage the unique properties of nucleic acids.
  1. Oligonucleotide Therapeutics:
    The journal primarily covers research on therapeutic oligonucleotides, including antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and their modifications to enhance efficacy and safety.
  2. Mechanisms of Action:
    It explores the molecular mechanisms of how nucleic acids interact with cellular machinery, including studies on RNA splicing, gene silencing, and the role of modifications on therapeutic effectiveness.
  3. Drug Development and Delivery Systems:
    Research on the preclinical and clinical development of nucleic acid therapeutics, including pharmacokinetics, biodistribution, and innovative delivery systems, is a core focus area.
  4. Clinical Applications and Innovations:
    The journal highlights clinical applications of nucleic acid therapies in treating genetic disorders, cancers, and infectious diseases, showcasing new therapeutic approaches and successes.
  5. Regulatory and Ethical Considerations:
    Discussion on the regulatory landscape, ethical considerations, and patient involvement in the development of nucleic acid therapeutics is also a significant aspect of the journal.
Nucleic Acid Therapeutics has seen a significant evolution in its focus, with several emerging themes reflecting the latest advancements and challenges in the field of nucleic acid-based therapies.
  1. RNA Modifications and Their Therapeutic Impacts:
    Recent publications emphasize the importance of RNA modifications in enhancing the therapeutic potential of oligonucleotides, indicating a trend towards optimizing oligonucleotide chemistry for improved efficacy.
  2. Personalized Medicine Approaches:
    The journal is increasingly featuring research on personalized medicine, particularly the development of individualized therapies for rare diseases and genetic disorders, demonstrating a shift towards tailored therapeutic strategies.
  3. Immunogenicity and Safety Assessments:
    There is a growing focus on assessing the immunogenicity and safety profiles of nucleic acid therapeutics, addressing concerns related to innate immune responses and off-target effects.
  4. Innovative Delivery Mechanisms:
    Emerging themes include advanced delivery mechanisms for nucleic acid therapeutics, such as the use of exosomes and targeted nanoparticles, which enhance the specificity and efficiency of therapy.
  5. In Vivo Applications and Clinical Trials:
    Increased emphasis is being placed on in vivo applications and clinical trial data, reflecting a trend towards translating laboratory findings into clinical settings, particularly for diseases like Duchenne muscular dystrophy and various cancers.

Declining or Waning

While Nucleic Acid Therapeutics continues to thrive in various areas, some themes have shown a decline in prominence in recent publications. This shift may reflect changing research priorities or advancements in related fields.
  1. Traditional Small Molecule Therapies:
    There has been a noticeable decline in research focused on traditional small molecule therapies in favor of more advanced nucleic acid-based approaches, which are now seen as more innovative and targeted.
  2. Non-Modified Oligonucleotides:
    Research on non-modified oligonucleotides has decreased as the community increasingly focuses on chemically modified oligonucleotides that offer improved stability, efficacy, and safety profiles.
  3. Conventional Delivery Methods:
    Studies exploring conventional delivery methods for oligonucleotides have become less common, as the field shifts towards developing more sophisticated delivery systems such as nanoparticles and conjugates.
  4. Basic Mechanistic Studies:
    There is a waning interest in basic mechanistic studies without translational implications, with a greater emphasis now on research that directly leads to clinical applications.

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