THERAPEUTIC DRUG MONITORING
Scope & Guideline
Advancing Pharmacology for Safer, More Effective Therapies
Introduction
Aims and Scopes
- Population Pharmacokinetics:
This area emphasizes the study of drug concentration variability among different populations, utilizing modeling techniques to optimize dosing strategies across diverse patient demographics. - Therapeutic Drug Monitoring Techniques:
The journal highlights advanced methodologies in drug monitoring, including liquid chromatography-tandem mass spectrometry (LC-MS/MS) and microsampling techniques, which facilitate accurate drug level assessment in clinical settings. - Clinical Applications and Case Studies:
TDM publishes case studies that illustrate the practical implications of drug monitoring, showcasing how tailored therapeutic approaches can improve patient outcomes, particularly in critical care and specialized populations. - Pharmacogenomics and Personalized Medicine:
The integration of pharmacogenomic data into drug monitoring practices is a focus area, as it allows for personalized dosing regimens that account for individual genetic variability affecting drug metabolism. - Drug-Drug Interactions and Safety Assessments:
The journal addresses the complexities of drug interactions and their potential impacts on therapeutic efficacy and safety, guiding clinicians in managing polypharmacy effectively.
Trending and Emerging
- Model-Informed Precision Dosing:
There is an increasing emphasis on model-informed approaches to dosing, utilizing pharmacokinetic models to tailor drug regimens for individual patients, particularly in complex cases such as renal impairment or obesity. - Integration of Artificial Intelligence and Machine Learning:
The application of AI and machine learning techniques to enhance drug monitoring practices is emerging, providing innovative solutions for predicting drug levels and optimizing therapeutic outcomes. - Focus on Pediatric and Geriatric Populations:
An uptick in research specifically addressing therapeutic drug monitoring in pediatric and geriatric populations is evident, as these groups often exhibit unique pharmacokinetic profiles and require specialized dosing strategies. - Use of Alternative Sample Matrices:
Research on alternative sample matrices, such as dried blood spots and saliva, is gaining traction, offering more convenient and less invasive options for therapeutic drug monitoring. - Pharmacogenetic Applications in Clinical Practice:
There is a growing trend towards integrating pharmacogenetic testing into therapeutic drug monitoring, allowing for more personalized treatment plans based on individual genetic profiles.
Declining or Waning
- Traditional Monitoring Approaches:
There is a noticeable decline in research focusing solely on traditional trough concentration monitoring, as newer methodologies such as area under the curve (AUC) estimation gain traction for their enhanced accuracy and clinical relevance. - General Population Studies:
The journal has seen a reduction in studies that broadly assess drug monitoring in general populations, with a shift towards more targeted research in specific patient groups or conditions, reflecting a move towards precision medicine. - Static Reference Ranges:
The use of static reference ranges for therapeutic drug levels is diminishing in favor of more dynamic and individualized approaches that consider patient-specific factors such as pharmacogenomics and real-time monitoring data. - Basic Pharmacokinetic Studies:
Research focused solely on basic pharmacokinetic parameters without clinical application or relevance to therapeutic outcomes is becoming less frequent, as the journal prioritizes studies that directly impact clinical practice.
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