ACS Synthetic Biology
Scope & Guideline
Exploring the Nexus of Biology and Engineering
Introduction
Aims and Scopes
- Synthetic Biology Tools and Techniques:
Development and optimization of various synthetic biology tools, including CRISPR/Cas systems, optogenetic tools, and biosensors that enable precise manipulation of genetic circuits and metabolic pathways. - Metabolic Engineering and Biosynthesis:
Research aimed at engineering microbial systems for the production of valuable compounds, including biofuels, pharmaceuticals, and specialty chemicals through metabolic pathway optimization. - Genetic Circuit Design and Characterization:
Focus on the design and analysis of synthetic genetic circuits, including logic gates, feedback loops, and regulatory networks to control cellular behavior in predictable ways. - Cell-Free Systems and Biomanufacturing:
Investigation of cell-free expression systems for protein synthesis and the use of these systems for rapid prototyping and high-throughput screening of biological parts. - Applications in Medicine and Environmental Biotechnology:
Exploration of synthetic biology applications in therapeutic development, diagnostics, and environmental monitoring, including engineered probiotics and biosensors for detecting pollutants.
Trending and Emerging
- Integration of Artificial Intelligence and Machine Learning:
The application of AI and machine learning techniques to optimize synthetic biology processes and predict outcomes is increasingly prominent, facilitating data-driven designs and enhancing experimental efficiency. - Synthetic Probiotic Engineering:
The engineering of probiotics for therapeutic applications is on the rise, reflecting an increased interest in developing living therapeutics that can interact with human microbiomes or target specific diseases. - Environmental Applications and Bioremediation:
Research focusing on the use of engineered microorganisms for environmental applications, including bioremediation and pollution detection, is becoming more prevalent as sustainability issues gain importance. - Optogenetics in Synthetic Biology:
The use of light-controlled systems to manipulate biological processes is trending, showcasing advancements in precision control of gene expression and cellular functions. - Modular and Combinatorial Approaches:
There is a growing trend towards modular design in synthetic biology, allowing for the flexible assembly of genetic components to create complex systems with specific functions.
Declining or Waning
- Traditional Genetic Engineering Methods:
As newer and more efficient techniques such as CRISPR and synthetic biology tools gain prominence, traditional genetic engineering methods may be receiving less attention in favor of more advanced methodologies. - Basic Biochemical Pathway Studies:
Research focused on the basic understanding of metabolic pathways without engineering applications may be declining as the field moves towards more applied research with direct industrial or therapeutic relevance. - Non-Model Organism Studies:
Research involving non-model organisms may be less frequently published, as the community increasingly relies on well-characterized systems that provide more predictable outcomes for synthetic biology applications.
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