BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Scope & Guideline
Connecting Research to Real-World Biological Applications
Introduction
Aims and Scopes
- Biochemical Mechanisms and Pathways:
Research articles that elucidate the underlying biochemical mechanisms governing cellular functions, metabolic pathways, and molecular interactions. - Biophysical Characterization:
Studies employing biophysical methods to investigate the structure, dynamics, and interactions of biomolecules, providing insights into their functional roles. - Molecular Biology and Genetics:
Research focusing on molecular biology techniques including CRISPR, gene expression, and epigenetic modifications, highlighting their implications in health and disease. - Nanotechnology in Medicine:
Exploration of nanotechnology applications for drug delivery systems, biomaterials, and diagnostic tools in medical science. - Plant and Microbial Biochemistry:
Investigations into the biochemical processes in plants and microorganisms, including stress responses, metabolic engineering, and interactions with pathogens. - Therapeutic Innovations:
Development of new therapeutic strategies and biomolecules for treating cancer, metabolic disorders, and infectious diseases. - Systems Biology and Computational Approaches:
Integration of computational biology and systems biology to model complex biological systems and predict molecular interactions.
Trending and Emerging
- Ferroptosis and Cell Death Mechanisms:
An increasing number of studies explore the role of ferroptosis in various diseases, particularly cancer, highlighting its potential as a therapeutic target. - CRISPR and Gene Editing Technologies:
Research utilizing CRISPR technology for gene editing applications is on the rise, reflecting its transformative impact on genetics and molecular biology. - Nanomedicine and Targeted Therapies:
The development of nanocarriers for drug delivery and targeted therapies is emerging as a significant trend, with a focus on improving therapeutic efficacy and reducing side effects. - Metabolic Reprogramming in Cancer:
There is a growing interest in understanding how metabolic pathways are altered in cancer cells, which could inform new treatment strategies. - Epigenetics and Gene Regulation:
Research focusing on epigenetic modifications and their roles in gene regulation and disease progression is gaining momentum, emphasizing the complexity of gene expression control. - Microbiome Research:
Studies examining the interactions between the microbiome and host health, particularly in relation to metabolic and immune responses, are increasingly prominent. - Biomolecular Dynamics and Structural Biology:
Advancements in techniques such as cryo-EM and X-ray crystallography are facilitating deeper insights into biomolecular structures and dynamics, driving research in structural biology.
Declining or Waning
- Traditional Medicinal Chemistry:
Research that primarily focuses on classical medicinal chemistry approaches has seen a decline as the field shifts towards more integrated and multidisciplinary approaches to drug discovery. - Basic Enzyme Kinetics Studies:
While enzyme kinetics remains a vital area, studies focusing solely on basic kinetics without exploring broader biological implications or applications have become less frequent. - Single-Molecule Biophysics:
Research concentrated solely on single-molecule techniques may be waning as more complex systems and multi-molecular interactions gain importance in understanding biological processes. - Non-specific Antimicrobial Mechanisms:
Studies detailing broad-spectrum antimicrobial mechanisms without specific targeting or innovative delivery methods have decreased, as research increasingly favors targeted and mechanism-based approaches. - In Vitro Models of Disease:
The focus on simplistic in vitro models has declined in favor of more complex and relevant systems, such as organ-on-a-chip technologies or patient-derived models, that better mimic in vivo conditions.
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