Genes & Diseases
Scope & Guideline
Connecting genetics to disease for transformative insights.
Introduction
Aims and Scopes
- Molecular Genetics and Disease Mechanisms:
Research exploring the genetic basis of diseases, including the identification of mutations, polymorphisms, and their roles in disease progression. - Transcriptional and Epigenetic Regulation:
Studies on how transcriptional control and epigenetic modifications influence gene expression in the context of various diseases. - Cancer Biology and Therapeutics:
Investigations into the molecular mechanisms of cancer, including tumor microenvironment interactions, signaling pathways, and therapeutic targets. - Immunology and Autoimmunity:
Research on immune responses in disease states, including the role of immune checkpoints, inflammatory pathways, and autoimmune conditions. - Stem Cell Biology and Regenerative Medicine:
Exploration of stem cell mechanisms, differentiation, and their therapeutic applications in disease treatment and tissue regeneration. - Metabolism and Disease:
Studies on metabolic pathways and their alterations in diseases such as obesity, diabetes, and cancer, focusing on therapeutic implications. - Neurobiology and Neurodegenerative Diseases:
Research into the genetic and molecular underpinnings of neurodegenerative diseases, including Alzheimer's and Parkinson's disease. - Infectious Diseases and Host Response:
Investigations into the genetic factors affecting susceptibility to infectious diseases and the host's immune response mechanisms.
Trending and Emerging
- Multi-Omics Approaches:
There is a growing emphasis on integrating genomic, transcriptomic, proteomic, and metabolomic data to provide a comprehensive understanding of disease mechanisms and therapeutic targets. - Precision Medicine and Personalized Therapies:
Research focused on tailoring treatment strategies based on genetic and molecular profiling of patients is gaining traction, reflecting the shift towards individualized healthcare. - Ferroptosis and Regulated Cell Death:
Ferroptosis, a form of regulated cell death, is emerging as a significant area of research, particularly in its implications for cancer therapy and neurodegenerative diseases. - Immunotherapy and Cancer Microenvironment:
Studies exploring the interactions between cancer cells and the immune microenvironment, including the role of immune checkpoints and tumor-infiltrating lymphocytes, are increasingly prominent. - Gene Editing Technologies:
The application and implications of CRISPR and other gene editing technologies in treating genetic disorders and cancers are trending, highlighting their potential for future therapies. - Role of Non-Coding RNAs in Disease:
Research into the functions and mechanisms of long non-coding RNAs (lncRNAs) and circular RNAs in various diseases is on the rise, emphasizing their potential as biomarkers and therapeutic targets. - Microbiome and Human Health:
Explorations of the relationship between the microbiome and various diseases, including metabolic and autoimmune conditions, are becoming a significant focus. - Neuroinflammation and Neurodegeneration:
Research on the mechanisms of neuroinflammation and its role in neurodegenerative diseases is gaining importance, reflecting a broader understanding of brain health.
Declining or Waning
- Traditional Genetic Association Studies:
While genetic association studies remain important, there has been a noticeable shift toward more integrative approaches that combine genomics with other omics data, leading to a decline in standalone genetic association studies. - Basic Mechanistic Studies Without Clinical Relevance:
Research that focuses solely on basic mechanisms without a clear clinical application or relevance is becoming less frequent, as the journal prioritizes studies with translational potential. - Single-Factor Analyses in Complex Diseases:
There is a decrease in studies that analyze single genetic or molecular factors in complex diseases, with a growing preference for multi-factorial and systems biology approaches. - Historical Reviews on Established Diseases:
Reviews focusing on well-established diseases without new insights or perspectives are waning, as the journal seeks fresh, innovative content that addresses current research gaps.
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