FEBS Journal
Scope & Guideline
Where Innovation Meets Molecular Insights
Introduction
Aims and Scopes
- Biochemical and Molecular Mechanisms:
The journal emphasizes studies that elucidate the biochemical pathways and molecular mechanisms underpinning cellular functions and disease processes, including signaling pathways, metabolic regulation, and enzyme function. - Structural Biology and Biophysics:
Research involving the structural characterization of biological macromolecules such as proteins and nucleic acids, utilizing techniques like X-ray crystallography, NMR, and cryo-electron microscopy, is a core focus. - Cellular and Developmental Biology:
The journal covers research on cellular processes, including cell differentiation, growth, and apoptosis, as well as developmental biology, exploring how these processes are regulated at the molecular level. - Cancer Biology and Therapeutics:
A significant emphasis is placed on studies related to cancer biology, including tumor microenvironment interactions, cancer stem cells, and novel therapeutic strategies. - Immunology and Microbiology:
The journal publishes articles on immune responses, pathogen-host interactions, and the microbiome's role in health and disease, reflecting the growing interest in these areas. - Neurobiology and Neurodegeneration:
Research addressing the molecular mechanisms of neurodegenerative diseases, neuroinflammation, and neuronal signaling is prominently featured, highlighting the journal's commitment to understanding brain health.
Trending and Emerging
- Cancer Immunotherapy:
Publications focusing on cancer immunotherapy have surged, highlighting the importance of understanding immune responses to tumors and the development of novel immunotherapeutic strategies. - Microbiome Research:
The role of the microbiome in health and disease is increasingly prominent, with studies examining its impact on various physiological processes and its potential as a therapeutic target. - Cellular Senescence and Aging:
Research on cellular senescence, its role in aging, and its implications for age-related diseases is gaining traction, reflecting a growing interest in understanding the biological mechanisms of aging. - Gene Editing Technologies:
The application of CRISPR and other gene editing technologies is increasingly featured, focusing on their potential for therapeutic interventions and understanding genetic diseases. - Metabolism and Disease:
Emerging studies on the links between metabolism, metabolic disorders, and diseases such as cancer and neurodegeneration are becoming more common, emphasizing the importance of metabolic pathways in health. - Extracellular Vesicles:
Research on extracellular vesicles and their roles in cell communication, disease progression, and potential therapeutic applications is gaining popularity, reflecting their significance in various biological processes.
Declining or Waning
- Basic Enzyme Kinetics:
Research focusing solely on basic enzyme kinetics has seen a decline, as the field increasingly emphasizes the integration of kinetic studies with structural biology and functional assays. - Traditional Pharmacology:
There is a noticeable reduction in studies centered on traditional pharmacological approaches, as the focus shifts towards molecular and genetic therapies, particularly in the context of cancer and chronic diseases. - Plant Biochemistry:
While still relevant, the volume of research specifically addressing plant biochemistry and physiology appears to be waning, potentially due to a shift towards more applied or translational research in agricultural biotechnology. - Studies on Model Organisms:
Research utilizing model organisms like yeast or Drosophila for basic biological questions is less frequent, with a trend towards more complex systems that reflect human biology more closely. - In Vitro Assays:
There seems to be a decline in the publication of studies relying solely on in vitro assays without further validation in vivo, as the scientific community increasingly values comprehensive approaches that include physiological relevance.
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