BIOORGANIC & MEDICINAL CHEMISTRY

Scope & Guideline

Innovating Drug Discovery Through Chemistry

Introduction

Welcome to the BIOORGANIC & MEDICINAL CHEMISTRY information hub, where our guidelines provide a wealth of knowledge about the journal’s focus and academic contributions. This page includes an extensive look at the aims and scope of BIOORGANIC & MEDICINAL CHEMISTRY, highlighting trending and emerging areas of study. We also examine declining topics to offer insight into academic interest shifts. Our curated list of highly cited topics and recent publications is part of our effort to guide scholars, using these guidelines to stay ahead in their research endeavors.
LanguageEnglish
ISSN0968-0896
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Support Open AccessNo
CountryUnited Kingdom
TypeJournal
Convergefrom 1993 to 2024
AbbreviationBIOORGAN MED CHEM / Bioorg. Med. Chem.
Frequency24 issues/year
Time To First Decision-
Time To Acceptance-
Acceptance Rate-
Home Page-
AddressTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND

Aims and Scopes

The journal 'BIOORGANIC & MEDICINAL CHEMISTRY' focuses on the intersection of organic chemistry and medicinal applications, emphasizing the design, synthesis, and biological evaluation of bioactive compounds. The scope encompasses a wide range of therapeutic areas, highlighting innovative methodologies and approaches in drug discovery.
  1. Medicinal Chemistry:
    Research devoted to the design and synthesis of new pharmaceutical agents, exploring their mechanisms of action and therapeutic potential.
  2. Bioorganic Chemistry:
    Studies on the chemical processes within and related to living organisms, including the synthesis of biomolecules and their interactions.
  3. Pharmacology and Drug Development:
    Investigations into the pharmacokinetics, pharmacodynamics, and therapeutic efficacy of newly developed compounds in various disease models.
  4. Chemical Biology:
    Research that bridges chemistry and biology, focusing on the development of chemical tools to study biological systems.
  5. Natural Products Chemistry:
    Exploration and modification of natural products to develop new therapeutic agents, including their structure-activity relationships.
  6. Bioconjugation and Drug Delivery Systems:
    Innovative strategies for enhancing drug delivery and targeting, including the use of conjugates and prodrugs.
The journal has seen a notable evolution in its thematic focus, with several emerging areas gaining traction. These trends reflect the dynamic nature of medicinal chemistry and its response to current global health challenges.
  1. PROTACs and Targeted Protein Degradation:
    The increasing interest in PROTACs (Proteolysis Targeting Chimeras) highlights a shift towards innovative strategies for targeted protein degradation, offering new avenues for therapeutic intervention.
  2. Immuno-oncology and Cancer Immunotherapy:
    Research on compounds that modulate immune responses to enhance anti-tumor activity is gaining momentum, reflecting the growing importance of immunotherapy in cancer treatment.
  3. RNA-targeted Therapeutics:
    With advancements in RNA biology, there is a rising focus on developing small molecules that target RNA structures, potentially leading to novel therapeutic agents.
  4. Nanotechnology in Drug Delivery:
    The integration of nanotechnology for drug delivery systems is increasingly prominent, focusing on improving bioavailability and targeting specific tissues.
  5. Natural Product Derivatives:
    There is renewed interest in modifying natural products to enhance their therapeutic properties, leveraging their complex structures and biological activity.
  6. Synthetic Biology Applications:
    Emerging research is increasingly focusing on the application of synthetic biology techniques for drug discovery and development, showcasing the interdisciplinary nature of modern medicinal chemistry.

Declining or Waning

While 'BIOORGANIC & MEDICINAL CHEMISTRY' continues to thrive in various domains, certain themes have shown a decline in prominence. These areas may reflect changing priorities in research focus or advancements in related fields.
  1. Traditional Antibiotic Development:
    Research in this area has decreased as focus shifts toward novel mechanisms of action and alternative therapeutic strategies to combat antibiotic resistance.
  2. Basic Organic Synthesis:
    Publications solely focused on the synthetic methodologies without direct application to biological systems are becoming less frequent as interdisciplinary approaches gain traction.
  3. Single-target Drug Discovery:
    The trend is moving towards multi-target approaches or combination therapies, leading to a reduction in publications centered on single-target compounds.
  4. In Vitro Studies without In Vivo Correlation:
    There is a waning interest in studies that do not extend beyond in vitro evaluations, as there is a growing emphasis on translational research that includes in vivo studies.

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