BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Scope & Guideline

Unraveling the complexities of medicinal chemistry.

Introduction

Welcome to the BIOORGANIC & MEDICINAL CHEMISTRY LETTERS information hub, where our guidelines provide a wealth of knowledge about the journal’s focus and academic contributions. This page includes an extensive look at the aims and scope of BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, highlighting trending and emerging areas of study. We also examine declining topics to offer insight into academic interest shifts. Our curated list of highly cited topics and recent publications is part of our effort to guide scholars, using these guidelines to stay ahead in their research endeavors.
LanguageEnglish
ISSN0960-894x
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Support Open AccessNo
CountryUnited Kingdom
TypeJournal
Convergefrom 1991 to 2024
AbbreviationBIOORG MED CHEM LETT / Bioorg. Med. Chem. Lett.
Frequency24 issues/year
Time To First Decision-
Time To Acceptance-
Acceptance Rate-
Home Page-
AddressTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND

Aims and Scopes

The journal 'BIOORGANIC & MEDICINAL CHEMISTRY LETTERS' focuses on the intersection of organic chemistry and medicinal applications, emphasizing the design, synthesis, and evaluation of novel compounds with therapeutic potential. The journal aims to provide a platform for rapid communication of significant advancements in drug discovery and development across various biological targets.
  1. Drug Design and Discovery:
    Research articles often delve into the rational design and synthesis of new drug candidates targeting various diseases, including cancer, infectious diseases, and neurodegenerative disorders.
  2. Medicinal Chemistry Approaches:
    The journal features studies employing cutting-edge medicinal chemistry techniques, including structure-activity relationship (SAR) studies, virtual screening, and computational modeling.
  3. Biological Evaluation:
    Acknowledging the importance of biological activity, the journal emphasizes the pharmacological evaluation of new compounds, assessing their efficacy and mechanisms of action in relevant biological models.
  4. Natural Products and Derivatives:
    Many publications explore the chemistry and bioactivity of natural products, examining their potential as lead compounds for drug development.
  5. Innovative Synthesis Methods:
    The journal promotes novel synthetic methodologies, including green chemistry approaches, microwave-assisted synthesis, and multi-component reactions, to enhance the efficiency of drug discovery.
Recent publications reflect emerging themes and trends that indicate the journal's evolving focus areas, highlighting the dynamic nature of medicinal chemistry research.
  1. PROTACs and Targeted Protein Degradation:
    The rise of proteolysis-targeting chimeras (PROTACs) showcases a trend towards innovative strategies for targeted protein degradation, reflecting a shift in therapeutic approaches to modulate protein levels in disease contexts.
  2. Immunotherapy and Checkpoint Inhibitors:
    A growing number of studies are dedicated to the design of immune checkpoint inhibitors and immunotherapeutic agents, indicating a strong interest in leveraging the immune system for cancer treatment.
  3. Nanoparticle and Drug Delivery Systems:
    Research on novel drug delivery systems, including nanoparticles and liposomes, has gained traction, emphasizing the importance of improving bioavailability and targeting in therapeutic applications.
  4. Natural Product Derivatives:
    The exploration of modified natural products for their therapeutic potential continues to trend, with a focus on enhancing bioactivity and overcoming resistance mechanisms.
  5. Machine Learning in Drug Discovery:
    The integration of machine learning and artificial intelligence in drug discovery processes is emerging as a significant trend, aiding in the prediction of compound interactions and optimizing lead identification.

Declining or Waning

While the journal remains vibrant, certain themes have shown a decline in frequency or prominence in recent publications. This may reflect shifts in research focus or emerging priorities within the field.
  1. Traditional Antibiotics:
    There has been a noticeable decrease in the publication of studies focused on traditional antibiotic compounds, likely due to the rising challenge of antibiotic resistance and a shift towards alternative therapeutic strategies.
  2. Single Target Inhibitors:
    Research focusing solely on single-target inhibitors has waned as the field moves towards multi-target and combination therapies that may offer broader efficacy against complex diseases.
  3. In vitro Studies Only:
    There is a trend away from studies that solely rely on in vitro evaluations without subsequent in vivo validation, indicating a growing expectation for comprehensive pharmacological assessments.

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