STRUCTURE

Scope & Guideline

Advancing the frontiers of structural and molecular biology.

Introduction

Immerse yourself in the scholarly insights of STRUCTURE with our comprehensive guidelines detailing its aims and scope. This page is your resource for understanding the journal's thematic priorities. Stay abreast of trending topics currently drawing significant attention and explore declining topics for a full picture of evolving interests. Our selection of highly cited topics and recent high-impact papers is curated within these guidelines to enhance your research impact.
LanguageEnglish
ISSN0969-2126
PublisherCELL PRESS
Support Open AccessNo
CountryUnited States
TypeJournal
Convergefrom 1993 to 2024
AbbreviationSTRUCTURE / Structure
Frequency12 issues/year
Time To First Decision-
Time To Acceptance-
Acceptance Rate-
Home Page-
Address50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139

Aims and Scopes

The journal 'STRUCTURE' primarily focuses on advancing the understanding of molecular architecture and dynamics through structural biology. The core aim is to elucidate the three-dimensional arrangements of biological macromolecules, how these structures relate to their functions, and how they can be manipulated for therapeutic purposes.
  1. Molecular Structure Determination:
    The journal emphasizes studies that employ various structural biology techniques such as X-ray crystallography, cryo-electron microscopy, and NMR spectroscopy to determine the atomic structures of proteins, nucleic acids, and complexes.
  2. Biological Mechanisms and Functionality:
    Research articles often explore how the structural features of biomolecules relate to their biological roles and mechanisms, offering insights into processes such as enzyme catalysis, receptor-ligand interactions, and cellular signaling pathways.
  3. Innovative Methodologies:
    The journal showcases advancements in methodologies for structural determination and analysis, including computational modeling, machine learning applications, and novel experimental techniques that enhance data quality and interpretability.
  4. Structural Insights into Disease Mechanisms:
    There is a consistent focus on how structural biology can elucidate the molecular basis of diseases, particularly in the context of drug design and therapeutic intervention, by revealing targets and mechanisms of action.
  5. Interdisciplinary Approaches:
    The journal promotes interdisciplinary research that integrates structural biology with biochemistry, molecular biology, and computational sciences, fostering a holistic understanding of biological systems.
The journal has shown a dynamic evolution in its thematic focus, particularly in response to contemporary challenges in structural biology. Emerging themes reflect the integration of technology, disease relevance, and innovative methodologies that are shaping the future of the field.
  1. Cryo-Electron Microscopy (Cryo-EM):
    A significant increase in studies utilizing cryo-EM has been observed, reflecting its growing importance in structural biology for providing high-resolution insights into large macromolecular complexes and their dynamics.
  2. Machine Learning and Computational Modeling:
    Recent publications demonstrate a surge in the application of machine learning techniques for predicting structures and understanding protein-ligand interactions, highlighting a trend towards computational approaches in structural biology.
  3. Structural Biology of Infectious Diseases:
    There is an increasing focus on the structural biology of pathogens, particularly in understanding the molecular mechanisms of viruses like SARS-CoV-2, which has implications for drug design and vaccine development.
  4. Dynamic and Functional Studies:
    Research that emphasizes the dynamics of biomolecules and their functional implications is on the rise, showcasing an interest in understanding how structural changes influence biological activity.
  5. Integration of Structural and Functional Data:
    An emerging trend is the integration of structural data with functional assays to provide a more comprehensive understanding of biomolecular interactions and mechanisms of action, reflecting a holistic approach to research.

Declining or Waning

While the journal maintains a robust focus on structural biology, certain themes have seen a decline in prominence over recent years. This may reflect shifting research priorities or advancements in methodologies that render previous approaches less central.
  1. Traditional Structural Biology Techniques:
    There appears to be a waning emphasis on classical approaches like NMR spectroscopy and crystallography as standalone techniques, with a shift towards integrating these methods with high-throughput and computational techniques.
  2. Basic Structural Studies Without Functional Context:
    Studies that focus solely on the determination of structure without linking to functional implications or biological relevance seem to be less favored, reflecting a trend toward more applied research.
  3. Static Structural Analysis:
    There is a noticeable decline in papers that solely present static structures, with a growing preference for dynamic studies that incorporate conformational changes and molecular dynamics simulations.
  4. Studies on Non-Protein Structures:
    Research focusing on non-protein biomolecules, while still relevant, has seen decreased visibility in the journal, possibly due to the increasing complexity and focus on protein structures and interactions.

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