Cell Chemical Biology
Scope & Guideline
Catalyzing Discoveries in Biochemistry and Beyond.
Introduction
Aims and Scopes
- Chemical Biology Techniques:
The journal encompasses a wide range of chemical biology techniques, including chemical proteomics, bioorthogonal chemistry, and small molecule discovery, providing insights into cellular processes. - Targeted Protein Degradation:
A significant area of focus is on targeted protein degradation, including the development of PROTACs (proteolysis-targeting chimeras) and their applications in cancer therapy and other diseases. - Metabolism and Disease:
Research frequently explores the role of metabolism in disease, particularly cancer and infectious diseases, highlighting how metabolic pathways can be targeted for therapeutic interventions. - Immunology and Therapeutics:
The journal features studies on immunology, including immune modulation and therapeutic strategies involving antibodies and small molecules, emphasizing their potential in treating various conditions. - RNA Biology:
An important aspect of the journal includes the investigation of RNA biology, focusing on RNA modifications, non-coding RNAs, and their roles in cellular regulation and disease. - Chemical Genomics:
The intersection of chemical biology and genomics is a key theme, with research aimed at understanding gene function and regulation through chemical probes and small molecules.
Trending and Emerging
- Induced Proximity Techniques:
Research on induced proximity, particularly through the use of molecular glues and PROTACs, has gained significant attention, highlighting innovative strategies for targeted degradation and modulation of protein functions. - Chemical Immunology:
The field of chemical immunology is expanding, with increasing studies focused on immune-modulating compounds and their applications in immunotherapy, particularly in cancer treatment. - Metabolomics and Disease:
An emerging focus on metabolomics is evident, with studies investigating how metabolic changes influence disease states and the potential for targeting metabolic pathways in therapy. - RNA-targeting Therapeutics:
There is a growing interest in RNA-targeting strategies, including the development of small molecules that can modulate RNA function and stability, reflecting the increasing recognition of RNA's role in cellular processes. - Synthetic Biology and Gene Editing:
Synthetic biology approaches, including CRISPR and other gene editing technologies, are increasingly featured, emphasizing their potential for therapeutic applications and biological research. - Dynamic Cellular Imaging:
Advancements in live-cell imaging techniques are trending, allowing researchers to visualize cellular processes in real-time, thereby enhancing our understanding of complex biological systems.
Declining or Waning
- Traditional Drug Discovery Approaches:
There appears to be a waning interest in traditional high-throughput screening methods for drug discovery, as newer, more targeted approaches like PROTACs and chemical genomics gain prominence. - Basic Biochemical Pathway Studies:
Research that solely focuses on elucidating basic biochemical pathways without a clear application or therapeutic angle has decreased, as the journal emphasizes translational research and practical applications. - Static Imaging Techniques:
Static imaging techniques have become less favored compared to dynamic and live-cell imaging approaches, which provide real-time insights into cellular processes. - Single Target Approaches:
There is a noticeable reduction in studies focusing on single-target drug discovery, as the field increasingly embraces polypharmacology and multi-target strategies. - Enzyme Mechanism Studies:
While still relevant, in-depth studies purely focused on enzyme mechanisms without broader implications for therapeutic development or biological context have become less prevalent.
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