Epigenomes
Scope & Guideline
Connecting Science and Discovery in Epigenomics
Introduction
Aims and Scopes
- Epigenetic Mechanisms in Disease:
Research on how epigenetic modifications contribute to the development and progression of diseases, including various cancers, cardiovascular diseases, and neurodegenerative disorders. - Environmental Influences on Epigenetics:
Exploration of how environmental factors, such as pollutants and dietary components, affect the epigenome and contribute to health disparities and disease susceptibility. - Epigenetic Regulation of Development:
Studies on the role of epigenetics in developmental processes, including stem cell differentiation, aging, and developmental disorders. - Technological Innovations in Epigenomics:
Advancements in technologies for profiling and analyzing epigenetic modifications, including multi-omics approaches, high-throughput sequencing, and bioinformatics tools. - Clinical Applications of Epigenetics:
Investigation of epigenetic markers as potential diagnostic tools and therapeutic targets, particularly in oncology and personalized medicine.
Trending and Emerging
- Multiomics Approaches:
An increasing trend towards integrating various omics layers (genomics, transcriptomics, metabolomics) to provide a comprehensive understanding of epigenetic regulation and its impact on health. - Epigenetics and Aging:
A growing interest in the role of epigenetic changes in aging processes and age-related diseases, emphasizing the potential for interventions that target epigenetic modifications. - Epigenetic Biomarkers for Disease Diagnosis:
Research focusing on the identification of epigenetic markers as reliable diagnostic tools for various diseases, particularly cancers, is becoming increasingly prominent. - Impact of Environmental Exposures on Epigenetics:
A significant rise in studies examining how environmental stressors, such as pollutants and lifestyle factors, influence epigenetic modifications and contribute to disease risk. - Therapeutic Applications of Epigenetic Modifiers:
An emerging focus on the development and application of drugs targeting epigenetic changes, known as 'epidrugs', to treat various conditions, particularly cancers.
Declining or Waning
- Basic Mechanisms of Epigenetic Regulation:
There has been a noticeable reduction in publications solely focused on foundational studies of epigenetic mechanisms, such as histone modification pathways, as newer research trends emphasize applications and implications. - Plant Epigenetics:
Although plant epigenetics has been an important area, recent publications suggest a waning interest compared to the growing focus on human health and disease-related epigenetics. - Single-Cell Epigenomics:
Research specifically targeting single-cell epigenomic analyses has seen less frequency, potentially overshadowed by broader multi-omics approaches that integrate various data types.
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