Epigenomics
Scope & Guideline
Exploring the Genetic Landscape of Cancer.
Introduction
Aims and Scopes
- Epigenetic Mechanisms in Disease:
The journal highlights research on how epigenetic modifications, such as DNA methylation and histone modification, contribute to the development and progression of diseases, particularly cancers and neurodegenerative disorders. - Environmental and Lifestyle Influences:
There is a strong emphasis on studies that investigate how environmental factors, lifestyle choices, and nutrition impact epigenetic changes and their subsequent effects on health outcomes. - Precision Medicine and Biomarkers:
The journal supports the development of epigenetic biomarkers for early diagnosis, prognosis, and treatment responses in various diseases, promoting the integration of epigenomics into precision medicine. - Non-coding RNAs and Epitranscriptomics:
Research on non-coding RNAs, including lncRNAs and miRNAs, is a core area, focusing on their roles in gene regulation and their potential as therapeutic targets. - Methodological Advances in Epigenomics:
The journal publishes articles on novel technologies and methodologies in epigenomics research, including high-throughput sequencing, bioinformatics approaches, and experimental models.
Trending and Emerging
- Integration of Multi-Omics Approaches:
There is a growing trend towards integrating epigenomics with genomics, transcriptomics, and proteomics to provide a more comprehensive understanding of biological processes and disease mechanisms. - Impact of Gut Microbiota on Epigenetics:
Research exploring the relationship between gut microbiota and epigenetic changes is emerging as a significant theme, linking microbiome studies with health and disease outcomes. - Epigenetics in Aging and Longevity:
Studies focusing on the role of epigenetics in aging processes and longevity are increasingly prevalent, highlighting how epigenetic modifications can influence lifespan and age-related diseases. - Epigenetic Therapy and Drug Development:
There is a notable increase in research aimed at developing epigenetic therapies, including small molecule inhibitors and gene editing technologies, as potential treatment options for various diseases. - Social and Environmental Epigenomics:
Emerging themes explore how social determinants and environmental exposures influence epigenetic modifications, emphasizing the role of epigenomics in public health and health disparities.
Declining or Waning
- Basic Mechanistic Studies:
There appears to be a waning interest in purely mechanistic studies that do not directly connect to clinical implications or applications, as the journal increasingly favors translational research. - Single-Factor Analysis:
Research focusing solely on single epigenetic modifications without considering the broader epigenomic landscape or interactions with other biological factors has seen a decrease in publication. - Animal Model Studies:
The use of traditional animal models for studying epigenetics, particularly when not linked to human health outcomes, is becoming less common, with a shift towards human studies and clinical relevance. - Historical Perspectives on Epigenetics:
Articles that focus on historical perspectives or reviews of epigenetics without new insights or data are less frequently accepted, as the journal prioritizes innovative and cutting-edge research.
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