NAR Cancer
Scope & Guideline
Empowering discovery in the fight against cancer.
Introduction
Aims and Scopes
- Molecular Mechanisms of Cancer:
Research focusing on the molecular and cellular processes that drive cancer, including DNA repair mechanisms, transcriptional regulation, and RNA modifications. - Cancer Genomics and Epigenomics:
In-depth studies on the genomic alterations associated with various cancers, including next-generation sequencing technologies and analyses of epigenetic changes. - Therapeutic Strategies and Resistance Mechanisms:
Investigations into novel therapeutic approaches and the mechanisms of drug resistance, particularly in relation to targeted therapies and immunotherapies. - Tumor Microenvironment and Immune Interactions:
Exploration of the interactions between tumor cells and their microenvironment, including immune evasion and the role of non-coding RNAs. - Data Integration and Computational Biology:
Utilization of bioinformatics and computational methods to integrate multi-omics data for better insights into cancer biology and treatment outcomes.
Trending and Emerging
- RNA Modifications and Translation Dynamics:
An increasing number of studies focus on the role of RNA modifications, such as m6A methylation, and their implications for translation control and cancer progression. - Extrachromosomal DNA and Genomic Instability:
Research into extrachromosomal DNA and its relationship with genomic instability is gaining traction, revealing new insights into cancer evolution and therapy resistance. - CRISPR and Gene Editing Technologies:
The application of CRISPR and other gene editing technologies is trending, with studies exploring their potential for targeted therapies and functional genomics in cancer. - Immune Microenvironment and Tumor Immunology:
There is a notable increase in research addressing the tumor immune microenvironment, emphasizing the importance of immune interactions in cancer therapy and patient prognosis. - Integration of Multi-Omics Data:
The trend towards integrating multi-omics data (genomics, transcriptomics, proteomics) is emerging, facilitating a comprehensive understanding of cancer biology and therapeutic responses.
Declining or Waning
- Traditional Chemotherapy Mechanisms:
Research focusing on classical chemotherapy mechanisms has decreased as attention shifts towards precision medicine and targeted therapies that better address the complexities of cancer. - Basic Histology and Morphological Studies:
Studies primarily centered on histological and morphological aspects of cancer are becoming less common, as molecular and genetic approaches gain precedence in understanding cancer biology. - Single-Agent Drug Studies:
The focus on single-agent drug efficacy studies is diminishing, with a greater emphasis now placed on combination therapies and multi-target approaches that reflect the complexity of cancer treatment.
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