JOURNAL OF PATHOLOGY
Scope & Guideline
Advancing the Science of Disease Understanding
Introduction
Aims and Scopes
- Molecular Pathology:
Research centered on the molecular mechanisms underlying diseases, including genetic alterations, epigenetic changes, and signaling pathways involved in disease progression. - Computational Pathology:
Utilization of machine learning and artificial intelligence to enhance diagnostic processes, including image analysis, classification of histopathological images, and predictive modeling. - Tissue Microenvironment Studies:
Exploration of the tumor microenvironment, including interactions between cancer cells and stromal components, and how these interactions influence tumor progression and response to therapy. - Pathogen-Host Interactions:
Investigations into how various pathogens, including viruses and bacteria, affect host cellular processes, contributing to disease pathogenesis. - Translational Research:
Research that bridges lab findings with clinical applications, focusing on improving therapeutic strategies and diagnostic tools based on pathological insights. - Immunopathology:
Study of the immune system's role in disease, including inflammation, autoimmune disorders, and the immune response to tumors.
Trending and Emerging
- Deep Learning and AI in Pathology:
A significant increase in the application of deep learning techniques for image analysis, aiding in diagnostics and prognostics, reflects the integration of artificial intelligence into pathology. - Microbiome Research:
Emerging studies focusing on the role of the microbiome in disease mechanisms are increasingly prevalent, highlighting the complex interactions between microbial populations and host health. - Cancer Microenvironment Dynamics:
Research emphasizing the interactions within the tumor microenvironment, including immune and stromal cell interactions, is gaining traction, indicating a shift towards understanding cancer as a systemic disease. - Regenerative Medicine and Tissue Repair:
An uptick in studies that focus on regenerative processes and the mechanisms of tissue repair, particularly in the context of chronic diseases and injuries. - Epigenetics in Disease:
Growing interest in the role of epigenetic modifications in disease pathogenesis and progression, indicating a shift towards understanding the regulatory mechanisms beyond genetic mutations.
Declining or Waning
- Traditional Histopathology:
While still important, there is a noticeable decline in studies solely focused on classical histopathological techniques without integration of modern imaging and computational methods. - Basic Histological Techniques:
Research focusing on basic staining and microscopy techniques is becoming less frequent, as new technologies and methodologies overshadow these foundational approaches. - Single Disease Focus Studies:
There is a trend away from studies that focus exclusively on single diseases in isolation, with a growing preference for research that integrates multiple diseases or complex pathologies. - In Vivo Animal Studies:
Research employing traditional in vivo models is declining, possibly due to the increased emphasis on human-relevant models and computational simulations.
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