JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
Scope & Guideline
Unraveling the Complexities of Mammary Gland Biology
Introduction
Aims and Scopes
- Mammary Gland Development and Physiology:
Research on the biological processes underlying mammary gland development, including cellular differentiation, hormonal regulation, and physiological functions. - Breast Cancer Biology and Pathophysiology:
Investigation into the molecular and cellular mechanisms of breast cancer, including tumor microenvironment interactions, signaling pathways, and genetic factors. - Preclinical Models and Experimental Techniques:
Development and utilization of various models (e.g., murine, bovine) and experimental techniques (e.g., organoids, 3D bioprinting) to study mammary gland biology and breast cancer. - Immune Response and Cancer Interaction:
Exploration of the immune landscape in the context of mammary gland biology and breast cancer, including immune cell contributions to tumor development and progression. - Comparative Studies Across Species:
Comparative analyses of mammary gland biology and breast cancer across different species to enhance translational research and understanding of the disease.
Trending and Emerging
- Single-Cell Analysis Techniques:
There is a notable increase in studies utilizing single-cell transcriptomic and spatial analysis to understand cellular heterogeneity in mammary glands and breast tumors, which is critical for personalized medicine. - 3D Bioprinting and Spatial Engineering:
Emerging methodologies such as 3D bioprinting for modeling mammary epithelial cell cultures are gaining attention, allowing for more sophisticated in vitro studies of tissue architecture and function. - Immunotherapy and the Tumor Microenvironment:
Research focusing on the immune microenvironment and its role in breast cancer progression and treatment response is becoming increasingly prominent, reflecting a shift towards immunotherapy strategies. - One Health Approach to Breast Cancer:
The exploration of male breast cancer within a One Health framework indicates a growing interest in understanding breast cancer from a broader biological and societal perspective. - Comparative Oncology:
Studies comparing mammary gland biology and cancer across species, particularly between canines and humans, are on the rise, emphasizing translational research opportunities and insights.
Declining or Waning
- Traditional In Vivo Models:
Research relying heavily on traditional in vivo models (e.g., rat models) for breast cancer studies may be waning as more advanced techniques such as organoid systems and patient-derived xenografts gain traction. - Basic Histological Techniques:
Studies focusing exclusively on basic histological analyses without integrating advanced imaging or molecular techniques are becoming less frequent, as the field moves towards more comprehensive approaches. - Single-agent Chemotherapy Studies:
Research concentrating solely on the efficacy of single-agent chemotherapies in breast cancer may be declining as the focus shifts toward combination therapies and personalized medicine approaches.
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