Oncogenesis
Scope & Guideline
Unlocking the molecular secrets of oncogenesis.
Introduction
Aims and Scopes
- Molecular Mechanisms of Cancer:
Research articles delve into the intricate molecular pathways that contribute to cancer initiation, progression, and metastasis, including studies on signaling pathways, genetic mutations, and epigenetic modifications. - Cancer Therapeutics and Resistance:
The journal publishes findings related to the development of novel therapeutic approaches, including targeted therapies and immunotherapies, as well as mechanisms of drug resistance that hinder treatment efficacy. - Cancer Stem Cells and Tumor Microenvironment:
A significant focus is placed on cancer stem cells, their role in tumor heterogeneity, and the influence of the tumor microenvironment on cancer progression and treatment response. - Advancements in Diagnostic and Prognostic Techniques:
The journal highlights innovative diagnostic tools and prognostic markers that facilitate early detection and personalized treatment strategies for various cancer types. - Translational Research and Clinical Applications:
Oncogenesis emphasizes studies that bridge laboratory findings with clinical applications, aiming to translate basic research into effective cancer treatments.
Trending and Emerging
- Targeting the Tumor Microenvironment:
Research is increasingly focusing on the tumor microenvironment and its role in cancer progression, therapy resistance, and immune evasion, highlighting the importance of understanding the interactions between tumor cells and their surrounding stromal cells. - Cancer Metabolism and Bioenergetics:
There is a growing trend towards investigating the metabolic reprogramming of cancer cells, with studies exploring how alterations in metabolism contribute to tumor growth and therapeutic resistance. - Immunotherapy and Immune Checkpoint Inhibition:
The exploration of immunotherapeutic strategies, particularly immune checkpoint inhibitors, is rapidly expanding, with research dedicated to understanding mechanisms of action, resistance, and combination therapies. - Precision Medicine and Personalized Therapy:
The journal is witnessing an increase in studies aimed at developing personalized treatment strategies based on genetic and molecular profiling of tumors, paving the way for more effective and tailored therapies. - Role of Non-Coding RNAs in Cancer:
Emerging research on the functional roles of non-coding RNAs (such as microRNAs and long non-coding RNAs) in cancer biology is gaining traction, providing insights into their potential as therapeutic targets and biomarkers.
Declining or Waning
- Traditional Chemotherapy Studies:
Research focused solely on traditional chemotherapy regimens is becoming less prevalent, as newer targeted therapies and immunotherapies gain prominence in cancer treatment, leading to a reduced emphasis on conventional approaches. - Single Agent Studies:
There is a noticeable decrease in publications centered around the efficacy of single-agent treatments, as the field increasingly prioritizes combination therapies that enhance treatment outcomes and reduce resistance. - Basic Histopathological Studies:
Basic histopathological studies that do not integrate molecular or genetic insights are being overshadowed by more comprehensive approaches that utilize multi-omics and systems biology to understand cancer biology. - Epidemiological Studies without Molecular Insights:
Epidemiological studies that lack a molecular component are becoming less frequent, as the emphasis shifts toward understanding the biological mechanisms driving cancer disparities and outcomes.
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