NITRIC OXIDE-BIOLOGY AND CHEMISTRY
Scope & Guideline
Unraveling the Complex Interactions of Nitric Oxide in Health and Disease
Introduction
Aims and Scopes
- Biological Mechanisms of Nitric Oxide and Hydrogen Sulfide:
The journal explores the biochemical pathways and physiological roles of nitric oxide and hydrogen sulfide, investigating their effects on various biological processes such as vasodilation, neurotransmission, and cellular signaling. - Therapeutic Applications and Innovations:
Research published in the journal highlights novel therapeutic strategies utilizing NO and H2S, including drug delivery systems, inhalation therapies, and their potential roles in treating various diseases, particularly cardiovascular and respiratory conditions. - Interactions with Other Biological Molecules and Pathways:
The journal examines the crosstalk between nitric oxide, hydrogen sulfide, and other signaling molecules, emphasizing the interplay of these gases with reactive oxygen species and their implications in health and disease. - Impact on Plant Physiology and Stress Responses:
Research also addresses the roles of NO and H2S in plant biology, particularly in responses to abiotic and biotic stress, showcasing their importance in agriculture and environmental science. - Systematic Reviews and Meta-Analyses:
The journal often publishes systematic reviews and meta-analyses that consolidate findings from various studies, providing comprehensive insights into the clinical implications of NO and H2S.
Trending and Emerging
- Nanotechnology in Drug Delivery:
There is a growing emphasis on the development of nanoparticle-based systems for targeted delivery of nitric oxide and hydrogen sulfide, showcasing advancements in materials science and therapeutic applications. - Role of Nitric Oxide in Neurodegenerative Diseases:
Recent studies indicate a significant increase in research exploring the involvement of nitric oxide in neurodegenerative diseases, highlighting its dual role as both a neuroprotective and neurotoxic agent. - Hydrogen Sulfide as a Therapeutic Agent:
Research focusing on hydrogen sulfide is emerging prominently, with increased investigations into its potential therapeutic roles, particularly in cardiovascular health and metabolic disorders. - Interplay Between Nitric Oxide and Gut Microbiome:
Emerging studies investigate the relationship between nitric oxide and gut microbiota, highlighting how NO may influence gut health and overall systemic inflammation. - Impact of Lifestyle Factors on Nitric Oxide Biology:
Recent publications emphasize the effects of dietary and lifestyle interventions on nitric oxide production and bioavailability, reflecting a trend towards personalized medicine and preventive health strategies.
Declining or Waning
- Traditional Therapeutic Applications:
There seems to be a waning focus on established therapeutic applications of nitric oxide, such as its use in treating conditions like angina and pulmonary hypertension, in favor of exploring more innovative and nuanced applications. - Basic Mechanistic Studies:
The journal has shifted towards more translational research, with fewer studies solely focused on basic mechanistic insights into nitric oxide and hydrogen sulfide signaling pathways, suggesting a move towards applied research with direct clinical implications. - Animal Model Studies:
There has been a noticeable reduction in the number of publications utilizing traditional animal models to study nitric oxide's effects, possibly due to the increasing emphasis on human clinical trials and translational research. - Focus on Nitric Oxide in Environmental Contexts:
Research addressing the environmental implications of nitric oxide, particularly in atmospheric chemistry and pollution, seems to be receiving less attention, as the journal narrows its focus to biomedical applications.
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