Non-coding RNA Research
Scope & Guideline
Illuminating the Roles of Non-Coding RNAs in Health and Disease
Introduction
Aims and Scopes
- Investigation of ncRNA roles in cancer biology:
The journal focuses extensively on the involvement of non-coding RNAs, such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), in the pathogenesis, progression, and treatment responses of various cancers. - Clinical applications and biomarker discovery:
Research published often explores the potential of ncRNAs as biomarkers for disease diagnosis, prognosis, and therapeutic targets, emphasizing their clinical relevance in conditions like cancer, diabetes, and neurodegenerative diseases. - Mechanistic insights into ncRNA functions:
A significant portion of the articles aims to elucidate the molecular mechanisms by which ncRNAs exert their effects, including their interactions with signaling pathways, gene expression regulation, and cellular processes. - Therapeutic innovations involving ncRNAs:
The journal encourages studies that investigate novel therapeutic strategies utilizing ncRNAs, including their application in drug resistance, targeted therapies, and gene editing approaches. - Interdisciplinary approaches to ncRNA research:
Research in this journal often integrates bioinformatics, molecular biology, and clinical studies, highlighting the importance of a multidisciplinary perspective in understanding the complexities of ncRNA functions.
Trending and Emerging
- Exosomal ncRNAs as diagnostic and therapeutic tools:
There is a rising trend in research focused on exosomal ncRNAs, highlighting their potential as biomarkers for various diseases and their role in intercellular communication, particularly in cancer and neurological disorders. - Circular RNAs in cancer and other diseases:
Circular RNAs are emerging as a significant area of interest, with numerous studies investigating their regulatory functions, involvement in disease mechanisms, and potential as therapeutic targets. - Interplay between ncRNAs and immune responses:
Recent publications are increasingly exploring how ncRNAs interact with immune pathways, influencing inflammation, and immune responses, which is critical for understanding diseases like cancer and autoimmune disorders. - Role of ncRNAs in metabolic disorders:
There is a growing body of work examining the contributions of ncRNAs to metabolic diseases, such as diabetes and obesity, indicating a broader application of ncRNA research beyond oncology. - Integrative multi-omics approaches:
The use of comprehensive multi-omics strategies to study ncRNAs in conjunction with genomics, proteomics, and metabolomics is on the rise, reflecting a trend towards understanding the complex regulatory networks involving ncRNAs.
Declining or Waning
- Basic research on ncRNA biogenesis:
There is a noticeable decrease in publications focusing solely on the fundamental aspects of ncRNA biogenesis, as the field has shifted towards more applied research with clinical implications. - Studies on non-coding RNAs in non-cancer diseases:
Research exploring the roles of ncRNAs in non-cancerous conditions, such as metabolic disorders or cardiovascular diseases, appears to be less frequent, possibly overshadowed by the pressing focus on cancer-related studies. - Exploratory studies without clear mechanisms:
There has been a reduction in publications that merely describe ncRNA expression profiles without delving into the underlying mechanisms or functional implications, as the field increasingly demands rigorous mechanistic insights. - Single-ncRNA studies:
Research centered on individual ncRNAs is becoming less common, with a growing preference for studies that examine networks and interactions among multiple ncRNAs and their targets, reflecting a more systems biology approach. - Overlapping themes with established journals:
Some topics related to ncRNAs, such as their roles in apoptosis or inflammation, are increasingly published in more specialized journals, indicating a potential waning of original contributions in these areas within this journal.
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