Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
Scope & Guideline
Transforming Our Understanding of Gene Regulation
Introduction
Aims and Scopes
- Gene Expression Regulation:
Research articles exploring the mechanisms and factors involved in the regulation of gene expression, including transcription factors, enhancers, and silencers. - Post-Translational Modifications:
Studies that investigate how post-translational modifications of proteins influence gene regulation and cellular functions, particularly in the context of diseases. - Non-Coding RNAs:
Papers focusing on the roles of non-coding RNAs, such as microRNAs and long non-coding RNAs, in regulating gene expression and their implications in various biological processes. - Chromatin Dynamics:
Research on how chromatin structure and modifications affect gene expression, including the roles of histone modifications and chromatin remodeling complexes. - Signal Transduction Pathways:
Investigations into how signaling pathways affect gene expression and regulatory mechanisms, particularly in relation to cancer and other diseases. - Epigenetics:
Articles that delve into epigenetic regulation, including DNA methylation and histone modifications, and their role in gene expression and developmental processes. - RNA Processing and Stability:
Research focusing on the mechanisms of RNA processing, stability, and decay, and how these processes impact gene expression.
Trending and Emerging
- Regulatory Non-Coding RNAs:
There is a growing interest in understanding the functions of non-coding RNAs in gene regulation, particularly their roles in cancer and cellular responses to stress. - Interplay of Epigenetics and Gene Regulation:
Research focusing on how epigenetic modifications, such as DNA methylation and histone modifications, interact with transcriptional regulation is on the rise, demonstrating the complexity of gene regulatory mechanisms. - Integrative Genomics and Systems Biology:
Emerging studies are increasingly adopting integrative approaches that combine genomics, transcriptomics, and proteomics to provide a holistic understanding of gene regulation. - Post-Translational Modifications and Disease:
The exploration of how post-translational modifications of proteins influence gene regulation in the context of various diseases, particularly cancer, is becoming more prominent. - Mechanisms of RNA Stability and Processing:
There is an increasing focus on the mechanisms that govern RNA stability, processing, and decay, as these processes are critical for the regulation of gene expression. - Circular RNAs and Their Roles:
Recent interest in circular RNAs has surged, particularly regarding their regulatory roles in gene expression and implications in different diseases.
Declining or Waning
- Classical Genetic Regulation:
Topics related to traditional models of genetic regulation, such as simple promoter analysis, have seen a decrease in frequency, possibly due to the rise of more complex and integrative approaches that encompass broader regulatory networks. - Basic Biochemical Mechanisms:
Basic studies focusing solely on biochemical pathways without integrating gene regulation insights are becoming less common, as the field increasingly emphasizes the interplay between biochemical mechanisms and gene expression. - Single-Gene Studies:
Research centered on the regulation of single genes has waned as the focus shifts towards understanding gene networks and systems biology approaches that consider multiple interacting genes and their regulatory elements. - Static Models of Gene Regulation:
The use of static models to describe gene regulation has decreased as dynamic and systems-level approaches gain prominence, reflecting the need for more comprehensive understanding of regulatory mechanisms.
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