NUCLEIC ACIDS RESEARCH
Scope & Guideline
Pioneering Research in Molecular Biology
Introduction
Aims and Scopes
- Nucleic Acid Structure and Function:
Research focusing on the structural and functional aspects of DNA and RNA, including studies on G-quadruplexes, ribozymes, and RNA modifications. - Gene Regulation and Expression:
Explorations of the mechanisms that control gene expression, including transcription factors, enhancers, silencers, and the role of non-coding RNAs. - DNA Repair and Replication:
Investigations into the molecular mechanisms of DNA repair pathways, replication processes, and the impact of various factors on genomic integrity. - CRISPR and Genome Editing Technologies:
Studies on the development and application of CRISPR and other genome editing technologies, including their mechanisms, efficiency, and specificity. - Epigenetics and Chromatin Dynamics:
Research addressing the role of epigenetic modifications and chromatin structure in regulating gene expression and maintaining genomic stability. - Bioinformatics and Computational Biology:
Development and application of computational tools and databases for analyzing nucleic acid sequences, structures, and interactions.
Trending and Emerging
- RNA Modifications and Function:
Research focusing on various RNA modifications, such as m6A and pseudouridylation, is gaining momentum, emphasizing their roles in gene regulation, stability, and cellular responses. - CRISPR Technologies and Applications:
There is a rapidly growing body of work exploring novel CRISPR applications, including base editing, epigenome editing, and their therapeutic potential in various diseases. - Synthetic Biology and RNA Engineering:
Emerging studies on engineered RNA molecules and synthetic biology approaches are trending, particularly in the context of developing novel therapeutics and gene regulation systems. - Phase Separation and Biomolecular Condensates:
Research on the role of phase separation in cellular organization and function is increasingly prominent, particularly in relation to RNA-binding proteins and their interactions. - Metagenomics and Microbiome Studies:
The integration of nucleic acid research with metagenomics and microbiome analysis is on the rise, showcasing the importance of microbial communities in health and disease. - Machine Learning in Genomics:
The application of machine learning techniques to analyze genomic data and predict functional outcomes is an emerging trend, facilitating more efficient data interpretation and discovery.
Declining or Waning
- Traditional Molecular Biology Techniques:
There has been a notable decrease in publications centered around classical molecular biology techniques, such as basic cloning and PCR methods, which have been largely supplanted by more advanced and sophisticated technologies. - Single-Gene Studies:
Research focusing on the characterization of single genes has diminished, as the field increasingly moves towards understanding complex interactions and networks involving multiple genes and regulatory elements. - Static Structural Studies:
Static studies that provide a snapshot of molecular structures without dynamic considerations are becoming less prominent, as researchers prioritize studies that incorporate dynamic and functional aspects of nucleic acids. - Basic RNA Isolation Techniques:
The frequency of articles dedicated solely to basic RNA isolation and purification techniques has decreased, as researchers now often integrate these methods within broader studies of RNA function and dynamics.
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