ONCOGENE
Scope & Guideline
Advancing Cancer Research Through Innovative Insights
Introduction
Aims and Scopes
- Molecular Mechanisms of Cancer:
Research in this area delves into the genetic, epigenetic, and proteomic alterations that contribute to the initiation and progression of various cancers. It emphasizes understanding the roles of oncogenes, tumor suppressor genes, and signaling pathways in tumor biology. - Tumor Microenvironment and Immune Interactions:
Studies address the complex interactions between tumor cells and their microenvironment, including the role of cancer-associated fibroblasts, immune cells, and extracellular matrix components in tumor progression and therapeutic responses. - Therapeutic Resistance Mechanisms:
This theme explores how cancer cells develop resistance to standard therapies, including chemotherapy and targeted treatments. Research often focuses on identifying novel targets and strategies to overcome resistance. - Cancer Stem Cells and Metastasis:
Research focuses on the properties of cancer stem cells and their role in metastasis, emphasizing the mechanisms that enable these cells to sustain tumor growth, resist therapies, and drive metastatic spread. - Innovative Therapeutic Strategies:
The journal highlights studies on novel therapeutic approaches, including targeted therapies, immunotherapies, and combination treatments, aimed at improving clinical outcomes for cancer patients. - Clinical and Translational Research:
ONCOGENE publishes research that bridges laboratory findings with clinical applications, emphasizing studies that have the potential to translate into improved patient care and outcomes.
Trending and Emerging
- Epigenetic Regulation in Cancer:
Research increasingly emphasizes the role of epigenetic modifications, such as DNA methylation and histone modification, in cancer progression and treatment resistance, suggesting new avenues for therapeutic intervention. - Non-coding RNAs and Tumor Biology:
There is a growing focus on the roles of long non-coding RNAs (lncRNAs) and microRNAs in regulating gene expression and their implications in cancer stemness, metastasis, and therapeutic resistance. - Metabolic Reprogramming of Cancer Cells:
Emerging studies investigate how cancer cells alter their metabolic pathways to support growth and survival, with a particular focus on targeting metabolic vulnerabilities as a therapeutic strategy. - Immunotherapy and Tumor Microenvironment Modulation:
The integration of immunotherapy into cancer treatment regimens is a significant trend, with research exploring how the tumor microenvironment influences immune responses and therapeutic efficacy. - Artificial Intelligence and Machine Learning in Oncology:
The application of AI and machine learning techniques for data analysis, patient stratification, and predictive modeling in cancer is rapidly gaining traction, leading to more personalized treatment strategies. - CRISPR and Gene Editing Technologies:
Research utilizing CRISPR and other gene editing technologies to investigate gene function and develop novel therapeutic approaches is on the rise, reflecting the potential for precision medicine in oncology.
Declining or Waning
- Traditional Chemotherapy Studies:
There is a noticeable decline in studies focused solely on traditional chemotherapy agents, as research increasingly shifts toward personalized medicine and targeted therapies that consider the specific molecular profiles of tumors. - Basic Cell Culture Studies:
Research relying solely on conventional 2D cell culture models is less frequent, as more studies adopt advanced in vivo models and 3D culture systems that better mimic the tumor microenvironment. - Single Biomarker Studies:
The trend is shifting away from single biomarker studies towards multi-omics approaches that integrate various molecular data types, reflecting a more comprehensive understanding of cancer biology. - Generalized Cancer Epidemiology:
There is a decline in broad epidemiological studies lacking molecular insights, as the focus moves towards understanding specific genetic and environmental interactions that contribute to cancer.
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