PLATELETS
Scope & Guideline
Unveiling the complexities of thrombosis and hemostasis.
Introduction
Aims and Scopes
- Platelet Function and Mechanisms:
Research on the fundamental roles of platelets in hemostasis and thrombosis, including activation pathways, aggregation mechanisms, and interactions with other blood components. - Clinical Applications and Therapeutics:
Studies investigating the efficacy and safety of antiplatelet therapies, platelet transfusions, and emerging treatments for conditions like immune thrombocytopenia and thrombotic disorders. - Platelet Pathophysiology in Disease:
Exploration of the involvement of platelets in various diseases, including cancer, infections, cardiovascular diseases, and immune disorders. - Technological Innovations in Platelet Research:
Development and application of novel methodologies and technologies, such as mass cytometry and microfluidic systems, to study platelet behavior and function. - Genetics and Molecular Biology of Platelets:
Investigations into genetic factors influencing platelet function and disorders, including studies on inherited thrombocytopenias and molecular signaling pathways.
Trending and Emerging
- Platelet Extracellular Vesicles and Microvesicles:
An increased focus on the roles of platelet-derived extracellular vesicles in communication and pathology, particularly in cancer and inflammatory diseases, highlighting their potential as biomarkers and therapeutic targets. - Personalized Antiplatelet Therapy:
Emerging research on tailoring antiplatelet therapy based on individual patient characteristics, including genetic factors and specific clinical settings, to improve treatment outcomes. - Platelets in Infectious Diseases and COVID-19:
Growing interest in the role of platelets in infectious diseases, particularly in the context of COVID-19, where their involvement in coagulopathy and immune responses is being actively explored. - Platelet-Mediated Immunity:
An increasing recognition of platelets as active participants in immune responses, with studies investigating their interactions with immune cells and implications in autoimmune conditions. - Technological Advances in Platelet Research:
Significant advancements in technologies such as single-cell analysis, high-throughput sequencing, and microfluidics are enabling more nuanced studies of platelet biology and function.
Declining or Waning
- Basic Hematology and Platelet Count Studies:
Research focusing primarily on basic hematological parameters and platelet counts, which has decreased in favor of more complex studies involving platelet function and molecular mechanisms. - Platelet Role in Traditional Hematological Disorders:
Topics related to classic hematological conditions, such as simple thrombocytopenias without a thorough understanding of underlying mechanisms, are becoming less frequent. - Animal Model Studies:
While animal model studies are still important, there is a noticeable decline in the publication of papers solely focused on basic animal model findings without translational implications.
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