RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
Scope & Guideline
Advancing Knowledge in Bioorganic Chemistry
Introduction
Aims and Scopes
- Bioorganic Synthesis:
Research on the synthesis of organic compounds with biological activity, including methods such as microwave-assisted synthesis, one-pot reactions, and various chemical transformations. - Biological Evaluation:
Studies assessing the biological activity of synthesized compounds, including antimicrobial, anticancer, and antioxidant properties, often utilizing in vitro and in vivo models. - Molecular Docking and Computational Studies:
Use of computational techniques to predict the interactions of compounds with biological targets, aiding in the design of more effective drugs. - Chemical Biology:
Exploration of the chemical basis of biological processes, including studies on enzyme activity, protein interactions, and the role of small molecules in cellular functions. - Natural Products and Their Derivatives:
Investigations into the extraction, characterization, and modification of natural compounds, with a focus on their pharmacological potential. - Nanotechnology in Drug Delivery:
Research on the design and application of nanoparticle systems for targeted drug delivery and enhanced therapeutic efficacy.
Trending and Emerging
- CRISPR and Gene Editing Technologies:
There is a significant increase in research focusing on CRISPR/Cas9 systems and their applications in gene editing, reflecting the growing interest in precision medicine and genetic engineering. - Anticancer Drug Development:
A rising number of studies are dedicated to the design and synthesis of novel anticancer agents, particularly those targeting specific pathways or utilizing combination therapies. - Synthetic Antimicrobial Peptides:
Research on synthetic antimicrobial peptides is gaining momentum as an alternative to traditional antibiotics, focusing on their mechanisms of action and potential applications in treating resistant infections. - Nanoparticle-Based Drug Delivery Systems:
Emerging studies emphasize the use of nanoparticles for targeted drug delivery and enhanced therapeutic effects, indicating a shift towards more sophisticated drug formulation strategies. - Bioinformatics and Computational Drug Design:
An increasing trend in the use of computational methods for drug design and prediction of biological activity showcases the integration of bioinformatics in modern medicinal chemistry. - Natural Products with Anticancer Activity:
There is a renewed interest in natural products, particularly those with promising anticancer properties, leading to innovative derivatives aimed at improving efficacy and reducing side effects.
Declining or Waning
- Traditional Antibiotics:
Research on conventional antibiotic compounds has diminished as attention shifts towards novel antimicrobial strategies and drug resistance mechanisms. - Plant Extracts for Antimicrobial Activity:
While still relevant, the exploration of plant extracts has decreased in favor of synthetic compounds and targeted drug design, reflecting a broader trend towards more controlled and reproducible results. - Basic Pharmacognosy Studies:
The focus on basic pharmacognosy, such as the chemical composition of less-studied plant species, has waned as researchers prioritize more impactful and direct therapeutic applications. - Biomolecular Characterization:
Although important, the detailed characterization of biomolecules without a direct application or therapeutic implication has seen reduced interest compared to studies with clear pharmacological outcomes. - Simple In Vitro Assays:
The reliance on basic in vitro assays without advanced molecular docking or in vivo validation has decreased, with a growing preference for more complex and informative experimental designs.
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