CANCER LETTERS
Scope & Guideline
Transforming discoveries into therapeutic realities.
Introduction
Aims and Scopes
- Molecular Mechanisms of Cancer:
Research articles often explore the molecular and cellular mechanisms underlying cancer development and progression, including genetic, epigenetic, and metabolic alterations. - Therapeutic Strategies:
The journal publishes studies on novel therapeutic approaches, including targeted therapies, immunotherapies, and combination treatments aimed at improving patient outcomes. - Tumor Microenvironment:
A significant focus is placed on the interactions between cancer cells and their microenvironment, including the roles of stromal cells, immune cells, and extracellular vesicles. - Clinical Research and Trials:
Cancer Letters includes articles detailing clinical trials and studies that aim to translate laboratory findings into effective treatments for cancer patients. - Emerging Technologies:
The journal highlights the use of advanced technologies, such as single-cell sequencing and CRISPR, to investigate cancer biology and develop new therapeutic strategies.
Trending and Emerging
- Immunotherapy and Immune Checkpoint Inhibition:
A significant increase in publications focusing on immunotherapy, particularly immune checkpoint inhibitors, reflects the growing importance of harnessing the immune system to combat cancer. - Targeted Therapies and Precision Medicine:
Research on targeted therapies that consider individual patient genetic profiles is trending, showcasing a movement towards personalized cancer treatment. - Metabolism and Cancer:
The exploration of metabolic pathways in cancer cells and their influence on tumor progression and treatment resistance is gaining momentum. - Extracellular Vesicles and Cell-Cell Communication:
There is a rising interest in the role of extracellular vesicles in cancer biology, particularly regarding their role in intercellular communication and tumor microenvironment modulation. - Cancer Stem Cells and Tumor Heterogeneity:
Studies investigating cancer stem cells and tumor heterogeneity are increasingly prominent, emphasizing the complexity of tumor biology and the need for novel therapeutic strategies.
Declining or Waning
- Traditional Chemotherapy Studies:
There has been a noticeable decline in articles solely focused on traditional chemotherapy regimens, as research increasingly shifts towards personalized medicine and targeted therapies. - Basic Epidemiological Studies:
The publication of basic epidemiological studies related to cancer incidence and prevalence has decreased, as more researchers are focusing on molecular and mechanistic insights. - Single Modality Treatment Approaches:
Research that emphasizes single modality treatments (e.g., surgery or radiation alone) is becoming less common, with a growing interest in combination therapies that include immunotherapy and targeted agents. - Static Models of Cancer Research:
There is a reduced emphasis on static models of cancer that do not account for the dynamic nature of tumor biology and the tumor microenvironment. - Generalized Biomarker Studies:
Studies focusing on generalized biomarkers without specific context or mechanistic insights are becoming less frequent, as researchers seek more precise and actionable biomarker identification.
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