CELL BIOLOGY AND TOXICOLOGY
Scope & Guideline
Exploring the Intersections of Life and Toxicity
Introduction
Aims and Scopes
- Cellular Mechanisms of Toxicity:
Exploration of the cellular and molecular mechanisms by which toxic substances induce damage, apoptosis, or alterations in cellular functions. - Therapeutic Targets and Interventions:
Identification and validation of novel therapeutic targets, with a focus on how cellular responses to toxic agents can inform treatment strategies for various diseases. - Role of Non-Coding RNAs:
Investigation into the roles of non-coding RNAs, including microRNAs and long non-coding RNAs, in regulating cellular responses to stress and toxicity. - Stem Cell Biology and Regenerative Medicine:
Research on the applications of stem cell-derived therapies to mitigate toxic effects and to restore cellular function in damaged tissues. - Environmental and Chemical Toxicology:
Assessment of the impact of environmental pollutants and chemicals on cellular health, with a focus on their mechanisms of toxicity and potential health implications. - Innovative Methodologies in Toxicology:
Development and application of novel experimental techniques, including high-throughput screening and advanced imaging methods, to study cellular responses to toxic substances.
Trending and Emerging
- Exosomal Communication and Biomarkers:
Increasing emphasis on the role of exosomes in cell communication and as potential biomarkers for various diseases, highlighting their significance in both diagnosis and therapeutic strategies. - CRISPR and Gene Editing Technologies:
Growing interest in utilizing CRISPR and related gene-editing technologies to explore gene function in the context of toxicity and disease, showcasing their potential for advancing personalized medicine. - Metabolic Reprogramming in Cancer:
A rising focus on how toxic agents influence metabolic pathways in cancer cells, revealing new insights into tumor biology and potential therapeutic targets. - Mechanisms of Ferroptosis and Other Non-Apoptotic Cell Death Pathways:
Emerging research into ferroptosis and other non-apoptotic forms of cell death, providing deeper understanding of their roles in disease processes and responses to toxic substances. - Nanoparticle Toxicity and Applications:
Increased investigation into the toxicity of nanoparticles, their cellular interactions, and potential therapeutic applications, reflecting the growing relevance of nanotechnology in biomedicine.
Declining or Waning
- Traditional Toxicological Assays:
Publications focusing on classical toxicological assays are becoming less frequent, as researchers shift towards more innovative, high-throughput methods that provide deeper insights into cellular responses. - In Vivo Toxicity Studies:
There is a noticeable reduction in studies primarily focused on in vivo toxicity assessments, with a growing preference for in vitro models that offer more controlled environments for examining cellular mechanisms. - Generalized Mechanisms of Cell Death:
Research that broadly discusses mechanisms of cell death without specific context or application is waning, as there is a trend towards more targeted studies investigating specific pathways and their implications in disease.
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