Disease Models & Mechanisms
Scope & Guideline
Connecting Research and Therapy in Disease Models
Introduction
Aims and Scopes
- Disease Modeling:
The journal emphasizes the creation and refinement of various disease models, including mouse, zebrafish, and cellular systems, to facilitate a better understanding of human diseases. - Mechanistic Insights:
Research published in the journal often delves into the cellular and molecular mechanisms underlying diseases, providing insights that can lead to novel therapeutic approaches. - Translational Research:
The focus is also on translational studies that aim to apply findings from basic research to clinical settings, thereby improving patient outcomes. - Multiscale Approaches:
The journal encourages research that integrates data from multiple scales, from molecular to organismal levels, to comprehensively understand disease processes. - Interdisciplinary Collaboration:
The journal promotes collaboration across disciplines, including genetics, pharmacology, and bioinformatics, to advance the understanding of disease mechanisms and develop effective interventions.
Trending and Emerging
- Organoid and Stem Cell Models:
The use of organoids and stem cell-derived models is on the rise, allowing for more physiologically relevant studies of human diseases and personalized medicine approaches. - Multi-Omics Approaches:
There is a growing trend towards integrating multi-omics data (genomics, transcriptomics, proteomics) to provide a holistic view of disease mechanisms, enhancing the understanding of complex interactions. - Host-Microbiome Interactions:
Research focusing on the interactions between host organisms and their microbiomes is emerging, particularly in the context of metabolic diseases and immune responses. - Therapeutic Target Discovery:
A notable increase in studies aimed at identifying novel therapeutic targets through advanced screening methods is evident, reflecting the journal's commitment to translational research. - Disease Relevance of Non-Coding RNAs:
The role of non-coding RNAs in disease mechanisms is gaining attention, with researchers increasingly exploring their potential as biomarkers and therapeutic targets.
Declining or Waning
- Traditional Animal Models:
While animal models remain crucial, there is a noticeable decline in studies solely relying on traditional mouse models, with a growing emphasis on more diverse and innovative models such as organoids and iPSCs. - Single-Focus Studies:
Research that concentrates on isolated aspects of disease mechanisms without considering broader biological contexts is becoming less common, as the field moves towards more integrative approaches. - Basic Descriptive Studies:
The journal is seeing fewer publications that provide only descriptive data without mechanistic insights, as there is a stronger demand for studies that elucidate underlying pathways or therapeutic implications. - Generalized Findings Across Diseases:
Papers that attempt to draw broad conclusions applicable to multiple diseases without specific mechanistic support are decreasing, as the field values specificity and targeted interventions.
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