NEOPLASMA
Scope & Guideline
Transforming Cancer Research into Clinical Practice
Introduction
Aims and Scopes
- Molecular Mechanisms of Cancer:
Research focusing on the underlying biological processes and molecular pathways that contribute to cancer development and progression, including studies on gene expressions, signaling pathways, and cellular interactions. - Therapeutic Strategies and Clinical Trials:
Papers that explore novel treatments, drug combinations, and clinical trial results aimed at improving patient outcomes in various cancer types. - Cancer Biomarkers and Diagnostics:
Studies aimed at identifying and validating biomarkers for cancer diagnosis, prognosis, and treatment response, facilitating personalized medicine approaches. - Tumor Microenvironment and Metastasis:
Research that investigates the interactions between tumor cells and their microenvironment, including the role of stromal cells, immune responses, and metastatic behavior. - Preclinical and Translational Research:
Emphasis on the development of innovative models and methodologies to study cancer, including in vitro and in vivo studies that bridge laboratory findings to clinical applications.
Trending and Emerging
- Targeted and Personalized Therapies:
An increasing number of studies are focusing on targeted therapies, particularly those tailored to specific genetic mutations and biomarkers, indicating a shift towards precision medicine in oncology. - Immunotherapy and Immune Checkpoint Inhibitors:
Research examining the mechanisms and efficacy of immunotherapies, particularly immune checkpoint inhibitors, is on the rise as these treatments become central to cancer management. - Ferroptosis and Novel Cell Death Mechanisms:
Emerging interest in ferroptosis and other forms of regulated cell death as potential therapeutic targets reflects a deeper understanding of cancer biology and treatment resistance. - MicroRNA and Long Non-Coding RNA Research:
Studies exploring the roles of microRNAs and long non-coding RNAs in cancer progression and therapy resistance are increasingly prevalent, highlighting the importance of non-coding RNA in tumor biology. - Cancer Metabolism and Metabolic Reprogramming:
Research focusing on the metabolic adaptations of cancer cells and how these can be targeted for therapeutic benefit is gaining traction, reflecting a broader interest in cancer cell biology.
Declining or Waning
- Traditional Chemotherapy Studies:
Research focused solely on traditional chemotherapy regimens is less frequent, as there is a growing emphasis on targeted therapies and immunotherapy approaches. - Basic Histopathological Studies:
Papers that primarily describe histopathological features without integrating molecular or genetic analyses are becoming less prominent, reflecting a shift towards more comprehensive approaches that combine multiple disciplines. - Single-Agent Drug Studies:
There is a noticeable decline in studies investigating the efficacy of single-agent therapies, as combination therapies and multi-modal treatment strategies are gaining more attention. - Non-Clinical Research:
Research that lacks translational relevance or direct clinical implications is decreasing, as the focus shifts towards studies that can directly inform clinical practice and patient care.
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