Redox Biology
Scope & Guideline
Innovating Research on Cellular Function and Pathology
Introduction
Aims and Scopes
- Redox Mechanisms in Health and Disease:
The journal explores how redox processes influence health and disease, including the role of oxidative stress in chronic diseases such as cancer, cardiovascular diseases, and neurodegenerative disorders. - Antioxidant Defense Systems:
Research published in Redox Biology frequently addresses the mechanisms and efficacy of various antioxidant systems, including enzymatic and non-enzymatic antioxidants, and their therapeutic implications in managing oxidative stress-related diseases. - Ferroptosis and Regulated Cell Death:
A significant focus is on ferroptosis and other forms of regulated cell death, examining their mechanisms, implications in various diseases, and potential as therapeutic targets. - Mitochondrial Function and Redox Signaling:
The journal highlights the relationship between mitochondrial function, bioenergetics, and redox signaling, investigating how mitochondrial dynamics and redox states affect cellular health and disease outcomes. - Nutritional and Environmental Influences on Redox Biology:
Research often examines how dietary components, environmental factors, and metabolic pathways modulate redox states and influence disease susceptibility and progression. - Innovative Therapeutic Strategies:
The journal publishes studies on novel therapeutic strategies targeting redox pathways, including the development of redox-modulating agents and their application in clinical settings.
Trending and Emerging
- Redox Modulation in Cancer Therapy:
There is a growing focus on how redox modulation can be leveraged in cancer therapy, particularly in the context of ferroptosis and other regulated cell death pathways, indicating a shift towards therapeutic applications. - Interplay Between Gut Microbiota and Redox Biology:
Emerging research highlights the interactions between gut microbiota and redox biology, investigating how microbial metabolites influence redox states and impact health and disease. - Redox Biology and Aging:
The relationship between redox processes and aging is gaining traction, with studies exploring how redox dysregulation contributes to age-related diseases and potential interventions to mitigate these effects. - Environmental Impacts on Redox States:
Research is increasingly addressing how environmental factors, including pollution and diet, affect redox homeostasis and contribute to disease pathology, particularly in the context of climate change and public health. - Systems Biology Approaches to Redox Regulation:
There is a trend towards employing systems biology approaches to understand the complex networks of redox regulation, integrating data across multiple biological scales and disciplines.
Declining or Waning
- Traditional Antioxidant Therapies:
Research focusing on traditional antioxidant therapies has seen a decline as new strategies and approaches to modulate redox biology emerge, emphasizing the need for more targeted and mechanism-based interventions. - Basic Redox Biochemistry Studies:
There has been a noticeable waning of publications centered solely on basic redox biochemistry, as the field increasingly emphasizes translational research and the application of redox biology in clinical contexts. - Static Models of Oxidative Stress:
Studies relying on static models of oxidative stress without consideration of dynamic biological systems have become less frequent, as researchers seek more complex and realistic models to study redox biology. - Single-Parameter Redox Measurements:
Research that focuses on single-parameter measurements of redox states is declining in favor of multi-parameter approaches that provide a more comprehensive understanding of redox dynamics in biological systems.
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