JOURNAL OF MOLECULAR BIOLOGY
Scope & Guideline
Innovative Insights into Biophysics and Structure
Introduction
Aims and Scopes
- Structural Biology and Molecular Dynamics:
Research highlighting the structures of biological macromolecules, such as proteins and nucleic acids, using techniques like X-ray crystallography, NMR, and cryo-EM. Studies often include insights into dynamic processes and conformational changes that are critical for biological activity. - Protein Interactions and Functionality:
Exploration of how proteins interact with each other and with other biomolecules, including studies on protein-protein interactions, enzyme mechanisms, and the role of post-translational modifications in regulating protein function. - Computational and Theoretical Approaches:
Use of computational models and simulations to predict molecular behavior, structural dynamics, and interactions. This includes machine learning applications in protein structure prediction and the analysis of large biological datasets. - RNA Biology and Mechanisms:
Focus on the structural and functional aspects of RNA, including its role in gene regulation, splicing, and the mechanisms of RNA-binding proteins. - Viral Mechanisms and Host Interactions:
Investigations into the molecular biology of viruses, their interactions with host cells, and the implications for disease and therapeutic interventions. - Molecular Mechanisms in Disease:
Research that elucidates the molecular underpinnings of diseases, particularly cancer and neurodegenerative disorders, often linking basic molecular biology to clinical applications.
Trending and Emerging
- Machine Learning and AI in Molecular Biology:
There is a notable increase in the application of artificial intelligence and machine learning techniques for predicting protein structures, interactions, and dynamics, showcasing a shift toward data-driven approaches in molecular biology. - Phase Separation and Biomolecular Condensates:
Research on the role of liquid-liquid phase separation in cellular processes and disease mechanisms is gaining momentum, reflecting a growing interest in how cellular organization impacts molecular interactions. - Intrinsically Disordered Proteins:
Studies focusing on intrinsically disordered regions of proteins and their roles in regulation, aggregation, and disease are becoming more prevalent, highlighting their importance in molecular biology. - Structural Insights into Viral Mechanisms:
There is an increasing focus on understanding the structural biology of viruses, particularly in the context of the COVID-19 pandemic, with studies detailing viral entry mechanisms and interactions with host factors. - Post-translational Modifications:
Research exploring the effects of post-translational modifications on protein function and interactions is trending, indicating a deeper understanding of protein regulation and signaling pathways.
Declining or Waning
- Classical Biochemical Techniques:
Traditional approaches such as basic enzyme kinetics and simple biochemical assays are less frequently highlighted, likely due to the increasing complexity and integration of molecular dynamics and computational methods. - Single-Cell Analysis:
Although still important, the emphasis on single-cell RNA sequencing and associated technologies appears to be waning, as broader genomic and proteomic approaches gain traction. - Basic Genetic Studies:
Research focused solely on genetic mapping and basic genetic functions without integration into broader molecular mechanisms or disease contexts is becoming less common.
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