CELLULAR ONCOLOGY
Scope & Guideline
Fostering Global Collaboration in Oncological Science
Introduction
Aims and Scopes
- Tumor Microenvironment and Immunology:
Research exploring the interactions between tumor cells and their microenvironment, including immune cells, stromal components, and extracellular matrix, is a core focus. Studies examine how these interactions influence tumor progression, metastasis, and therapeutic responses. - Molecular Pathways and Targeted Therapies:
The journal highlights the identification and characterization of key molecular pathways involved in cancer biology. It covers research aimed at developing targeted therapies that exploit these pathways, including studies on gene expression, signaling networks, and resistance mechanisms. - Cellular Mechanisms of Cancer Progression:
CELLULAR ONCOLOGY publishes studies that elucidate the cellular mechanisms underlying cancer progression, including cell signaling, apoptosis, autophagy, and metabolic reprogramming. This includes investigations into how cancer cells adapt to survive and thrive in hostile environments. - Biomarker Discovery and Clinical Implications:
The journal emphasizes the discovery of biomarkers for cancer diagnosis, prognosis, and treatment response. Research that translates findings from laboratory studies to clinical settings, aiming to improve personalized medicine approaches, is particularly valued. - Innovative Therapeutic Strategies:
Research on novel therapeutic strategies, including immunotherapy, gene therapy, and combination treatments, is a major focus. The journal aims to showcase advancements in therapeutic approaches that enhance efficacy and reduce resistance in cancer treatment.
Trending and Emerging
- Immunotherapy and Immune Microenvironment Modulation:
There is a growing emphasis on immunotherapy, particularly studies investigating how to modulate the immune microenvironment to enhance anti-tumor responses. Research on immune checkpoint inhibitors and CAR-T cell therapies is increasingly prevalent. - Precision Oncology and Genomic Profiling:
The trend towards precision oncology is highlighted by studies utilizing genomic and transcriptomic profiling to inform treatment decisions. This includes identifying biomarkers that predict response to specific therapies, reflecting a personalized approach to cancer treatment. - Exosome and Extracellular Vesicle Research:
Research focusing on exosomes and other extracellular vesicles is on the rise, particularly regarding their roles in intercellular communication, drug delivery, and as biomarkers for cancer diagnosis and prognosis. - Metabolic Reprogramming in Cancer:
Emerging studies are increasingly exploring the role of metabolic pathways in cancer development and progression. Understanding how cancer cells reprogram their metabolism for survival and growth is gaining traction, with implications for therapeutic targeting. - 3D Culture and Organoid Models:
The use of 3D culture systems and organoids to study cancer biology and drug responses is trending. These models offer more physiologically relevant platforms for testing therapeutics and understanding tumor behavior compared to traditional 2D cultures.
Declining or Waning
- Traditional Chemotherapy Mechanisms:
Research specifically targeting traditional chemotherapy mechanisms has decreased, as the field increasingly shifts towards understanding targeted therapies and immunotherapy. Studies focusing solely on the mechanisms of classic chemotherapeutic agents are becoming less prominent. - Basic Cell Culture Studies:
Papers concentrating on basic in vitro cell culture studies without translational implications are less frequently published. The journal now favors studies that integrate clinical relevance and translational research, indicating a waning interest in purely foundational laboratory work. - Single Agent Drug Studies:
There is a noticeable decline in studies focusing on the effects of single-agent drugs in isolation. The trend is moving towards combination therapies and multi-target approaches, reflecting the complexity of cancer treatment and the need for more effective strategies. - Mechanistic Studies Without Clinical Context:
Research that explores cancer biology at a mechanistic level without linking findings to clinical outcomes or therapeutic implications has seen reduced emphasis. The journal prioritizes studies that can translate findings into clinical applications.
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